Mesrine: Killer Instinct -- the first of two parts -- charts the outlaw odyssey of Jacques Mesrine (Vincent Cassel), the legendary French gangster of the 1960s and 1970s who came to be known as French Public Enemy No. 1 and The Man of a Thousand Faces. Infamous for his bravado and outrageously daring prison escapes, Mesrine carried out numerous robberies, kidnappings and murders in a criminal career that spanned continents until he was shot dead in 1979 by France's notorious anti-gang unit....

Montreal, Canada. A down-on-his luck dentist, "Oz" Oseransky (Matthew Perry), discovers that his new neighbor is Jimmy "The Tulip" Tudeski (Bruce Willis), former mob-contract-killer-turned-police-informant upon whose head the Hungarian mob has put a steep price. Egged on by his loathsome wife, Sophie (Rosanna Arquette), Oz sets off to Chicago to let the mob know where The Tulip is and hopefully claim part of the reward.